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Our results show that a functional RNA-binding motif is decisive for NS1 of A/PR/8/34 virus to suppress IFN induction.
Technology is a source of support and communication as well as tension, and couples say it has both good and bad impacts on their relationships.
One in ten Americans have used an online dating site or mobile dating app; 66% of them have gone on a date with someone they met through a dating site or app, and 23% have met a spouse or long term partner through these sites.
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The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency.
Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion.
However there is now growing evidence that ZIKV infections may be linked to fetal and newborn microcephaly and serious neurological complications, such as Guillain–Barré syndrome.
To date, no clinically approved vaccines or therapeutics are available to prevent and control ZIKV infection.
The virulence of influenza A virus (FLUAV) is determined by several factors, including the viral polymerase complex, the viral glycoproteins hemagglutinin (HA) and neuraminidase (NA), and the two nonstructural proteins PB1-F2 and NS1 (40, 42).